Artemin is a novel member of the glial cell line-derived neurotrophic factor (GNDF) ligand family. Current evidence suggests that Artmenin signals through the receptor complex, GFRalpha3-RET, to influence neuron survival in vitro and in vivo. Recombinant human Artemin is a disulfide-linked homodimer, non-glycosylated polypeptide chain.
AGGPGSRARA AGARGCRLRS QLVPVRALGL GHRSDELVRF RFCSGSCRRA RSPHDLSLAS LLGAGALRPP PGSRPVSQPC CRPTRYEAVS FMDVNSTWRT VDRLSATACG CLG