life science research products, biological research products, biotechnology
Use * as wildcard:
compcells
trific
iclines

NALCN Antibody, clone S187-7, rat

NALCN Antibody, clone S187-7, rat
print page
Size: 100 µg
$294.00
Add to basket
Catalogue number:
SMC-417D
Name:
NALCN Antibody, clone S187-7, rat
Supplier:
Availability:

Mouse Anti-Rat NALCN Monoclonal IgG1. Protein G Purified

Data sheet:

Click to view / download

Applications:

WB, ICC/IF
SPECIFICITY: Detects ~200kDa. 1 µg/ml of SMC-417 was sufficient for detection of NALCN in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP asthe secondary antibody.; CELLULAR LOCALIZATION: Membrane

Product Type:
Antibodies - primary
Alternative Names:
VGCNL1, CanIon, Sodium leak channel non-selective protein, Voltage gated channel-like protein 1, A530023G15Rik, bA430M15.1, FLJ23913, FLJ44659, FLJ44764, Four repeat voltage gated ion channel, MGC74524, Putative 4 repeat voltage gated ion channel, Sodium
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Fusion protein amino acids 1659-1738 (cytoplasmic C-terminus) of rat NALCN
Storage Temp:
-20ºC
Accession Number:
NP_705894.1
Antibody Host:
Mouse
Antibody Isotype:
IgG1
Antibody Type:
Monoclonal
Clone Number:
S187-7
Reference:
1. Lee, J.H., Cribbs, L.L. and Perez-Reyes, E. (1999)FEBS Lett. 445: 231-236. 2. Lu, B., Su, Y., Das, S., Liu, J., Xia, J. and Ren, D. (2007) Cell 129: 371-383. 3. Jospin, M., et al. (2007) Curr. Biol. 17: 1595-1600. 4. Gaultier, C. and Gallego, J. (2008) Appl. Physiol. 104: 1522-1530. 5. Yeh, E., et al. (2008) PLoS Biol. 6: e55.
Specifications:
1 μg/mL of SMC-417 was sufficient for detection ofNALCN in 20μg of rat brain lysate by colorimetricimmunoblot analysis using Goat anti-mouse IgG:HRP asthe secondary antibody. immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
UNSPSC Code:
12352209
Additional Information:
TARGET: NALCN ; GENE ID: 266760; SWISSPROT: Q6Q760; BACKGROUND: NALCN (sodium leak channel non-selective protein), alsoknown as CanIon or VGCNL1 (voltage gated channel-like protein 1), is a 1738 amino acid multi-pass membrane protein that belongs to the cation-nonselective channel family. NALCN is highly conserved in mammals and is widely expressed in the central nervous system. Activated by NK-1R, NALCN is a voltage-independent, nonselective cation channel which is permeable to sodium, potassium and calcium ions. NALCN is responsible for background sodium ion leak conductance in neurons and regulates basal excitability of the nervous systems. Defects of NALCN in mice causes disruption in respiratory rhythm and death occurs within 24 hours of birth. Three isoforms of NALCN exists due to alternative splicing events.