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Potassium Channel Modulator Array Library

Library Code: T-VDAK+
 
Venoms from scorpions, snakes and spiders are rich sources of new K+ tools. The Potassium Channel Targeted Venom Discovery Array™ libraries contain pure venom fractions from 12, 24, 48 or 96 species optimized for identification of novel tools. Each array contains literature-cited, characterized venoms active on potassium channels as positive controls. The other venom fractions making up the library have been specially selected by our drug discovery scientists to maximize novel hit potential.
 
T-VDAK+ control venoms include:
  • Dendroaspis polylepis (black mamba snake) where Dendrotoxin K1 was discovered
  • Pandinus imperator (emperor scorpion) where several selective potassium channel tools have been discovered2
  • Grammostola rosea (Chilean rose tarantula) which also contains a diverse collection of toxins including gating modifiers3
References
  1. Smith L.A., Lafaye P.J., LaPenotiere H.F., Spain T., Dolly J.O. (1993). Cloning and functional expression of dendrotoxin K from black mamba, a K+ channel blocker. Biochemistry 32:5692-5697
  2. Rogowski R.S., Collins J.H., O'Neill T.J., Gustafson T.A., Werkman T.R., Rogawski M.A., Tenenholz T.C., Weber D.J., Blaustein M.P. (1996). Three new toxins from the scorpion Pandinus imperator selectively block certain voltage-gated K+ channels. Mol. Pharmacol. 50:1167-1177
  3. Swartz K.J., MacKinnon R. (1995). An inhibitor of the Kv2.1 potassium channel isolated from the venom of a Chilean tarantula. Neuron 15:941-949
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