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Pain Therapeutics Array Library

Library Code: T-VDAPain
 
Specifically designed to maximize discovery of new analgesic tools. Ion channels are very important pain targets along with receptors such as opioids and acetylcholine. Venoms from theraphosids (tarantulas), scorpions and snakes are rich sources of new analgesic tools. The Pain Targeted Venom Discovery Array™ libraries contain pure venom fractions from 12, 24, 48 or 96 species optimized for identification of novel tools. Each array contains literature-cited, characterized venoms active in analgesic pathways as positive controls. The other venom fractions making up the library have been specially selected by our drug discovery scientists to maximize novel hit potential.
 
T-VDAPain control venoms include
  • Thrixopelma puriens (Peruvian velvet tarantula) where Protox II, a gating modifier of NaV1.71, was discovered
  • Leiurus quinquestriatus (death stalker scorpion) where opioid selective tools have been discovered2
  • Dendroaspis polylepis (black mamba) venom which contain mambalgins3 - potent and selective ASIC channel tools
References
  1. Priest B.T., et al. (2007). ProTx-I and ProTx-II: gating modifiers of voltage-gated sodium channels. Toxicon 49:194-201
  2. Martin-Eauclaire MF et al (2010). Involvement of endogenous opioid system in scorpion toxin-induced antinociception in mice. Neurosci Lett. Sep 20;482(1):45-50
  3. Diochot, S. et al. (2012). Black mamba venom peptides target acid-sensing ion channels to abolish pain. Nature 490, 552-555
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