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Insecticide Array Library

Library Code: T-VDAInsect
 
Venoms are a rich source of insect-specific toxins as many arthropods have evolved these toxins for efficient prey capture. Insect-specific toxins from theraphosids (tarantulas) and scorpions are the most likely to yield the most useful materials. The Insecticide Targeted Venom Discovery Array™ libraries contain pure venom fractions from 12, 24, 48 or 96 species optimized for identification of novel tools. Each array contains literature-cited, characterized venoms active at insect targets as positive controls. The other venom fractions making up the library have been specially selected by our drug discovery scientists to maximize novel hit potential.
 
T-VDAInsect control venoms include:
  • Leiurus quinquestriatus (death stalker scorpion) which contains several insect-specific toxins – excitatory and inhibitory1
  • Brachypelma smithi (Mexican red-kneed tarantula) venom that contains insect-specific sodium channel toxins with no mammalian activity2
  • Phoneutria nigriventer (Brazilian armed spider) venom which contains another insect-specific neurotoxin3
References
  1. Kopeyan C., Mansuelle P., Sampieri F., Brando T., Bahraoui E.M., Rochat H., Granier C. (1990). Primary structure of scorpion anti-insect toxins isolated from the venom ofLeiurus quinquestriatus quinquestriatus. FEBS Lett. 261:423-426
  2. Corzo G., Diego-Garcia E., Clement H., Peigneur S., Odell G., Tytgat J., Possani L.D., Alagon A. (2008). An insecticidal peptide from the theraposid Brachypelma smithispider venom reveals common molecular features among spider species from different genera. Peptides 29:1901-1908
  3. Figueiredo S.G., Lima-Perez Garcia M.E., Valentim A.D.C., Cordeiro M.N., Diniz C.R., Richardson M. (1995). Purification and amino acid sequence of the insecticidal neurotoxin Tx4(6-1) from the venom of the 'armed' spider Phoneutria nigriventer. Toxicon 33:83-93
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