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Cytotoxins Array Library

Library Code: T-VDActox
 
Cytotoxins are important drug tools for a range of applications including oncology and cellular mechanisms. Venoms from snakes (vipers and elapids) as well as scorpions are rich sources of new cytotoxins with various mechanisms. The Cytotoxic Targeted Venom Discovery Array™ libraries contain pure venom fractions from 12, 24, 48 or 96 species optimized for identification of novel tools. Each array contains literature-cited, characterized venoms with cytotoxic activity as positive controls. The other venom fractions making up the library have been specially selected by our drug discovery scientists to maximize novel hit potential.
 
T-VDActox control venoms include:
  • Naja nigricollis (black-necked spitting cobra) which contains three finger toxins1
  • Crotalus ruber (red diamondback rattlesnake) where the cytotoxic activity is from multiple enzymatic mechanisms2
  • Scorpio maurus (Israeli gold scorpion) which also contains a diverse collection of cytotoxic peptides3
References
  1. Kalam, Y., Isbister, & G. K., Mirtschin, P., Hodgson, W.C., & Konstantakopoulos, N. (2010). Validation of a cell-based assay to differentiate between the cytotoxic effects of elapid snake venoms. Journal of Pharmacological and Toxicological Methods 1–6.
  2. Obrig, T. G., Louise, C. B., & Moran, T. P. (1993). Direct Cytotoxic Effects of Hemorrhagic Toxins from Crotalus ruber ruber and Crotalus atrox on Human Vascular Endothelial Cells, in Vitro. Microvascular Research 46, 412–416.
  3. Abdel-Rahman, M. A., Omran, M. A. A., & Abdel-Nabi, I. M. (2010). Neurotoxic and cytotoxic effects of venom from different populations of the Egyptian Scorpio maurus palmatus. Toxicon 55, 298–306.
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