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Cardiovascular Disease Array Library

Library Code: T-VDACV
 
Snake venoms are a rich source of new cardiovascular tools such as C-type lectins, serine proteases, natriuretics and a wealth of signaling peptides. The Cardiovascular Targeted Venom Discovery Array™ libraries contain pure venom fractions from 12, 24, 48 or 96 species optimized for identification of novel tools. Each array contains literature-cited, characterized venoms active in analgesic pathways as positive controls. Other venom fractions making up the library have been specially selected by our drug discovery scientists to maximize novel hit potential.
 
T-VDACV control venoms include:
  • Crotalus adamanteus (eastern diamondback rattlesnake) where several bradykinin potentiating peptides have been discovered1
  • Dendroaspis angusticeps (eastern green mamba) where several novel natriuretic peptides have been discovered2
  • Bitis gabonica (Gaboon viper) venom which contains a large abundance of serine proteases and, in particular, rhinocerase3
References
  1. Wermelinger L.S., Dutra D.L., Oliveira-Carvalho A.L., Soares M.R., Bloch C. Jr., Zingali R.B. (2005). Fast analysis of low molecular mass compounds present in snake venom: identification of ten new pyroglutamate-containing peptides. Rapid Commun. Mass Spectrom. 19:1703-1708
  2. Vink S, Jin A.H., Poth K.J., Head G.A., Alewood P.F., (2012). Natriuretic peptide drug leads from snake venom. Toxicon. Mar 15;59(4).
  3. Vaiyapuri S., Harrison R.A., Bicknell A.B., Gibbins J.M., Hutchinson G. (2010). Purification and functional characterisation of rhinocerase, a novel serine protease from the venom of Bitis gabonica rhinoceros. PLoS ONE 5:E9687-E9687
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