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ASIC Modulator Array Library

Library Code: T-VDAASIC
 
ASIC channel tools from theraphosids (tarantulas) and snakes are the most potent and selective agents currently known. The ASIC Targeted Venom Discovery Array™ libraries contain pure venom fractions from 12, 24, 48 or 96 species optimized for identification of novel tools. Each array contains literature-cited, characterized venoms active on ASIC channels as positive controls. Other venom fractions making up the library have been specially selected by our drug discovery scientists to maximize novel hit potential.
 
T-VDAASIC control venoms include: 
  • Psalmopoeus cambridgei (Trinidad chevron tarantula) which contains Psalmotoxin, a selective blocker of ASIC1a channels1
  • Dendroaspis polylepis (Black mamba) venom which contains Mambalgins that block ASIC1a/2a heteromers2
  • Dendroaspis angusticeps (Eastern green mamba) venom which contains mambalgin-3 that blocks ASIC1a and ASIC1b channels as well as 1a/2b heteromers3.
References  
  1. Escoubas P., de Weille J.R., Lecoq A., Diochot S., Waldmann R., Champigny G., Moinier D., Menez A., Lazdunski M. (2000). Isolation of a tarantula toxin specific for a class of proton-gated Na+ channels. J. Biol. Chem. 275:25116-25121
  2. Diochot S., Baron A., Salinas M., Douguet D., Scarzello S., Dabert-Gay A.-S., Debayle D., Friend V., Alloui A., Lazdunski M., Lingueglia E. (2012). Black mamba venom peptides target acid-sensing ion channels to abolish pain. Nature 490:552-555
  3. Schweitz H., Diochot S., Baron A., Salinas M., Lingueglia E. (2013). Venom toxins in the exploration of molecular, physiological and pathophysiological functions of acid-sensing ion channels. Submitted (FEB-2013) to UniProtKB C0HJB0
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