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Antimicrobials Array Library

Library Code: T-VDAMicrobe
 
With antibiotic resistance a significant global threat, venoms are proving a rich source of new molecules. The Antimicrobial Targeted Venom Discovery Array is specifically designed to maximize discovery of new tools. Novel antimicrobial peptides and proteins have been found in venoms from snakes, spiders and scorpions. The Antimicrobial Targeted Venom Discovery Array™ libraries contain pure venom fractions from 12, 24, 48 or 96 species optimized for identification of novel antimicrobials. Each array contains literature-cited, characterized venoms active on microbial growth and survival as positive controls. The other venom fractions making up the library have been specially selected by our drug discovery scientists to maximize the novel hit potential.
 
T-VDAMicrobe control venoms include:
  • Naja kaouthia (monocled cobra) as well as many other snake venom proteins such as phospholipase A2 and L amino acid oxidase, which have been shown to be bacteriocidal1
  • Pandinus imperator (emperor scorpion) where several antimicrobial peptides have been discovered2
  • Psalmopoeus cambridgei (Trinidad chevron tarantula) where antiplasmodial ICK peptides have been discovered3
References
  1. Samy RP, Stiles BG, Gopalakrishnakone P, Chow VT. (2011). Antimicrobial proteins from snake venoms: direct bacterial damage and activation of innate immunity againstStaphylococcus aureus skin infection. Curr. Med. Chem. 18(33):5104-13
  2. Zeng XC, Zhou L, Shi W, Luo X, Zhang L, Nie Y, Wang J, Wu S, Cao B, Cao H. (2013). Three new antimicrobial peptides from the scorpion Pandinus imperator. Peptides. 45C:28-34
  3. Choi S.-J., Parent R., Guillaume C., Deregnaucourt C., Delarbre C., Ojcius D.M., Montagne J.-J., Celerier M.-L., Phelipot A., Amiche M., Molgo J., Camadro J.-M., Guette C. (2004). Isolation and characterization of Psalmopeotoxin I and II: two novel antimalarial peptides from the venom of the tarantula Psalmopoeus cambridgei. FEBS Lett. 572:109-117
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