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Antibacterial Array Library

Library Code: T-VDAbacterial
 
With antibiotic resistance a significant global threat, venoms are proving a rich source of new molecules. The Antibacterial Targeted Venom Discovery Array™ is specifically designed to maximize discovery of new tools. Novel antimicrobial peptides and proteins have been found in venoms from snakes, spiders and scorpions. The Antibacterial Targeted Venom Discovery Array libraries contain pure venom fractions from 12, 24, 48 or 96 species optimized for identification of novel antibacterials. Each array contains literature-cited, characterized venoms active on microbial growth and survival as positive controls. The other venom fractions making up the library have been specially selected by our drug discovery scientists to maximize the novel hit potential.
 
T-VDAbacterial control venoms include:
  • Naja kaouthia (monocled cobra) as well as many other snake venom proteins such as phospholipase A2 and L-amino acid oxidase, which have been shown to be bacteriocidal1
  • Pandinus imperator (emperor scorpion) where several antimicrobial peptides have been discovered2
  • Grammostola spatuala (Chilean rose tarantula) containing antibacterial GsMTX433
References
  1. Samy RP, Stiles BG, Gopalakrishnakone P, Chow VT. (2011). Antimicrobial proteins from snake venoms: direct bacterial damage and activation of innate immunity againstStaphylococcus aureus skin infection. Curr. Med. Chem. 18(33):5104-13
  2. Zeng XC, Zhou L, Shi W, Luo X, Zhang L, Nie Y, Wang J, Wu S, Cao B, Cao H. (2013). Three new antimicrobial peptides from the scorpion Pandinus imperator. Peptides. 45C:28-34
  3. Jung HJ, Kim PI, Lee SK, Lee CW, Eu YJ, Lee DG, Earm YE, Kim JI. (2006) Lipid membrane interaction and antimicrobial activity of GsMTx-4, an inhibitor of mechanosensitive channel. Biochem. Biophys. Res. Commun. 10;340(2):633-8. Epub 2005 Dec 19.
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